Glutathione Barrier Cream

Name: Glutathione Barrier Cream
Rating: 5.00 (6 reviews)

(6)

A Glutathione (5,000 ppm) barrier-finishing cream with a 5-type ceramide complex, Squalane, and 6 peptides that seals in tone correction while strengthening the skin's protective layer.

Seals in the tone correction work of the Glutathione Toning Ampoule.
5-type ceramide complex (NP, NG, NS, AP, AS, EOP) for comprehensive barrier rebuilding.
Squalane for fast-absorbing, non-greasy protective moisture all year round.
6 peptides + Niacinamide for firmness and radiance support at the final step.

Size 50 ml / 1.69 fl. oz.

Quantity

Estimated delivery between November 16 and November 18. Order within .

Vegan formula
Fragrance-free
99% purity Glutathione (30,000 ppm)
Free from 8 types of preservatives (including parabens)
Dermatologically tested

Glutathione Barrier Cream

$26.00

Protects the progress you've made

Applied as the final step after the Glutathione Toning Ampoule, this cream seals in tone-correction results and prevents environmental factors from disrupting the skin.

Five ceramide types for a real barrier

Five distinct ceramide types (Ceramide NP, NG, NS, AP, AS) plus Phytosphingosine and Cholesterol work together to rebuild and reinforce the skin's lipid matrix.

Squalane for non-greasy moisture

Squalane is structurally similar to skin's own sebum, absorbing without the heavy or occlusive feeling of heavier creams. The protective layer it forms is breathable in all seasons.

All-in-one glow + firmness finishing step

Glutathione (5,000 ppm), Niacinamide, six peptides, and Adenosine continue addressing tone, clarity, and elasticity even after your routine is complete.

Clinical Trial Results

Clinically proven. Every result below comes from independent testing. Exact figures, no estimates. Individual results may vary.

Hydration That Lasts

After a single application, surface hydration jumped from 38.45 to 66.12 — and was still at 44.28 after 250 hours, vs. 38.46 for untreated skin. Deep hydration followed the same pattern, remaining elevated at 37.42 at the 250-hour mark.

What this means for you:

One application keeps skin measurably more hydrated for over 10 days. You're not just moisturizing for today.

Barrier Recovery After Damage

After SLS-induced barrier damage, skin treated with the cream recovered elasticity to 0.81 and hydration to 38.87 after 2 weeks — both surpassing the pre-damage baseline, vs. 0.75 and 33.36 for untreated skin.

What this means for you:

This test intentionally broke the skin barrier, then measured recovery. The cream didn't just restore skin to where it started — it came back stronger. That's genuine barrier repair.

Results based on instrumental testing. SLS model is a standard method for simulating barrier disruption in cosmetic efficacy research. Individual results may vary.

5-Type Ceramide Complex + Squalane

Ceramides are the skin's natural barrier lipids—and this cream includes five distinct types (NP, NG, NS, AP, AS, EOP) alongside Phytosphingosine and Cholesterol to create the most complete barrier support in the Deepondé range. Squalane mirrors skin's own oils, allowing the cream to absorb quickly and protect effectively without heaviness or shine.

Water (Aqua), Glycerin, Butylene Glycol, Squalane, Bis-Hydroxyethoxypropyl Dimethicone, Niacinamide, Dicaprylyl Ether, Polyglyceryl-3 Methylglucose Distearate, Caprylic/Capric/Myristic/Stearic Triglyceride, Cetearyl Alcohol, Methyl Trimethicone, Benzyl Glycol, Palmitic Acid, Stearic Acid, Helianthus Annuus (Sunflower) Seed Oil, Glyceryl Stearate, Glutathione (5,000 ppm), Tromethamine, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Cetearyl Glucoside, Behenyl Alcohol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Theobroma Cacao (Cocoa) Seed Butter, Allantoin, Ethylhexylglycerin, Dipotassium Glycyrrhizate, Disodium EDTA, Adenosine, Hydrogenated Lecithin, Sorbitan Isostearate, Polyglyceryl-10 Stearate, Tocopherol, Panthenol, Sodium Ascorbyl Phosphate, Ceramide NP, Caprylyl Glycol, 1,2-Hexanediol, Phytosphingosine, Cholesterol, Ceramide NG, Ceramide NS, Ceramide AP, Ceramide AS, Pyridoxine, Folic Acid, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Tripeptide-1, Copper Tripeptide-1, Acetyl Hexapeptide-8, Biotin, Hexapeptide-9, Cyanocobalamin, Nonapeptide-1, Thiamine HCl, Beta-Carotene, Riboflavin, Linoleic Acid, Ceramide EOP

Deepondé Difference

Deepondé uses a proprietary 354-hour extraction process (Vintage 3310™)—steaming, drying, and vacuum-concentrating Tremella Fuciformis repeatedly to maximize polysaccharide potency. This level of commitment to a single ingredient is what makes Deepondé's plant-based hydration different from the rest.

For Best Results

How to Use

As the final step of your skincare routine, take an appropriate amount and gently apply to the face and neck, spreading smoothly until absorbed.

Extra tips:

Apply both morning and night for continuous protection.
In the morning, follow with SPF 30+ to protect tone-correction results from UV exposure.
Use directly after Glutathione Toning Ampoule for the full Deepondé Glutathione routine.
Works well as the sealing final layer alongside other serums or ampoules.

For external use only. Avoid contact with eyes. If eye contact occurs, rinse thoroughly with water. If irritation or rash persists, consult a doctor. Keep out of reach of children. To ensure skin compatibility, conduct a patch test before use.

Explore More Products

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Signature Origin Mask

Intensive sheet mask

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Glutathione Toning Ampoule

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Signature Origin Mist

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FAQs

View all FAQs

Glutathione Barrier Cream is particularly suited for those finishing a tone-correcting routine who want to protect and extend those results. It's also excellent for skin with a weakened or disrupted barrier—anyone experiencing sensitivity, dullness, or easy redness will benefit from the ceramide complex.

Yes—that's when it's most useful. A weakened barrier is one of the main reasons skin looks dull and uneven. This cream stabilizes and protects without adding any additional irritation.

No. Squalane is the primary oil base—it's skin-identical, meaning it absorbs quickly and leaves a comfortable finish without greasy heaviness. The overall texture is designed for day and night use in all seasons.

No. The high-adherence texture means it sits smoothly under morning makeup without disruption. It helps subsequent products adhere evenly and comfortably.

Yes. Glutathione Barrier Cream is designed to be the final step in any routine. When used as the finishing layer over Glutathione Toning Ampoule, you can expect a synergistic effect that combines barrier repair, moisture, tone support, and firmness into one cohesive regimen.

General Questions

Each Deepondé product has a recommended placement in the routine, which you'll find on its product page under How to Use. As a general principle: lighter textures and calming first steps go earlier; sealing and moisture-barrier products go last. If you're building a routine from the beginning, Signature Origin 100 is the place to start.

Every formula in the Deepondé range is developed with a minimal ingredient list, free from fragrance, essential oils, and the most common skin-irritating additives. Each product is dermatologically tested. That said, individual skin varies — a patch test before first use is always recommended.

All Deepondé products are formulated for daily and night use. Some, like the sheet mask, work well as a weekly ritual or on-demand step; others are designed to be part of your morning and evening routine. Specific guidance is on each product page.

Deepondé is built around a slow but sure approach. Most people notice an immediate change in comfort and texture from the first use. Visible shifts — in elasticity, tone clarity, or pore appearance — develop over several weeks of consistent use. Results compound quietly rather than announcing themselves early.

5 stars: 6 (100%)
4 stars: 0 (0%)
3 stars: 0 (0%)
2 stars: 0 (0%)
1 star: 0 (0%)

I have hormonal acne and struggle with oily skin, so I am hesitant to try anything new. This exceeded my expectations as my skin did not get greasy even throughout the day. I have noticed my skin seems firmer, less irritated, and more even.

I use this with signature origin 100 and was in love with the combo. I was worried I would be "too hydrated" but somehow it hydrates without making the skin greasy.

It has a typical, moderately thick texture. At first glance, I expected it to feel oily, but once it's on the skin, it actually feels more hydrating. It also feels like it forms a slight protective layer, so if I apply it before bed, my skin stays hydrated until morning, which is perfect! The next day after using it, I also feel like my complexion looks noticeably clearer, which is amazing!

일반적인 적당꾸덕 제형으로 처음 딱 봤을 땐 유분감이 많을 것 같은데, 막상 피부에 올리면 수분감이 더 많이 느껴졌어요.
살짝 막씌워지는 느낌도 들어서 자기전에 바르고 자면 아침까지 건조하지 않아서 딱 좋아요 !
사용후 다음날 피부보면 안색이 딱 맑아져있는 느낌도 들어서 최고에요

This cream seems perfect for the autumn-to-winter transition weather we're having right now. It feels thick at first, but it absorbs into the skin, leaving only moisture, which is a really unique texture. I haven't been using it for long, so I can't say much about a dramatic brightening effect yet, but my skin does feel a bit brighter, so I'm going to keep using it consistently.

지금처럼 가을-겨울 넘어가는 날씨에 찰떡인 크림인 것 같아요.
꾸덕한 듯 한데 피부에 바르면 스며들어 촉촉함만 남는게 신기한 제형입니다.
써본지 며칠되지 않아 엄청난 미백효과는 잘 모르겠지만, 뭔가 밝아진 느낌이라 한 번 꾸준하게 써보려해요

Ever since I hit my 30s, I've been really into trying different things for dark spots and blemishes. I saw an ad for this on Instagram, and the design looked so much more luxurious than other dark spot creams, so I thought, "Why not give it a try?" and bought it. And wow, I love it! After using it for about a week, I feel like my complexion has brightened up a bit. But the best part is, when I use it as a night cream before bed, my skin feels super hydrated all night long.

30대에 접어들어서 기미잡티에 이것저것 관심이 많았는데
인스타 광고 보고 다른 브랜드 기미크림보다 디자인도 고급스러워서 한 번 써볼까하고 구매했는데 너무 좋아요.
일주일 정도 써보니까 안색이 조금 밝아진 것 같고, 무엇보다 나이트케어로 바르고 자면 밤새 촉촉한 느낌이에요

I've been using the ampoule and cream for a few days since I got them, and I love them! My skin tone also seems brighter, and while the cream feels rich, it's refreshing and hydrating. It's the perfect cream to use in weather like this. I'll definitely keep using it!

앰플과크림 받고 몇일써본결과 너무 좋아요.
얼굴톤도 밝아진것같고 크림 발림 느낌이
꾸덕하지만 산뜻하고 촉촉하고
지금 같은 날씨에 쓰기 딱 좋은 크림이네요.
꾸준히 잘 쓸께요

I bought this because I noticed a lot more sunspots seemed to have popped up after my summer vacation!
I was torn between this and an ampoule, but I figured, 'It's the changing season, so a cream is the way to go!' I've been using it for 5 days now and I'm really happy with it~
My sunspots seem to have lightened a bit, and it gives my dry skin plenty of moisture, which makes me even more satisfied! 👍

이번 여름에 휴양지를 다녀오면서 기미가 많이 올라온 듯 하여 구매해보았습니다!
앰플과 고민하다가 환절기니까 크림이지! 싶어서 구매해봤는데 사용 5일차인 지금은 만족하며 사용중입니다~
기미가 조금 옅어진 것 같고, 건성인 피부에 보습감이 부족하기 않아서 더 만족스러워요 👍